{"id":77814,"date":"2019-04-09T12:25:43","date_gmt":"2019-04-09T08:25:43","guid":{"rendered":""},"modified":"-0001-11-30T00:00:00","modified_gmt":"-0001-11-29T20:00:00","slug":"","status":"publish","type":"post","link":"https:\/\/ucnoqta.az\/?p=77814","title":{"rendered":"Az\u0259rbaycanda bu d\u0259rmanlar Qada\u011fan edilib<\/b><\/font>"},"content":{"rendered":"

Az\u0259rbaycanda fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259rinin idxal\u0131, p\u0259rak\u0259nd\u0259 v\u0259 topdan sat\u0131\u015f\u0131 qada\u011fan edilib. <\/strong><\/p>\n

Ucnoqta.az x\u0259b\u0259r verir ki, bu bar\u0259d\u0259 "Report"a S\u0259hiyy\u0259 Nazirliyind\u0259n m\u0259lumat verilib. <\/p>\n

Bildirilib ki, Avropa D\u0259rman Agentliyinin 15 fevral tarixli EMA\/114407\/2019 nömr\u0259li “Ür\u0259k ritm probleml\u0259ri yaratmas\u0131 il\u0259 ba\u011fl\u0131 potensial risk s\u0259b\u0259bind\u0259n fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259rinin qeydiyyat\u0131n\u0131n dayand\u0131r\u0131lmas\u0131” adl\u0131 s\u0259n\u0259d d\u0259rc edilib.<\/p>\n

S\u0259n\u0259d\u0259 \u0259sas\u0259n Avropa D\u0259rman Agentliyinin (EMA) farmakon\u0259zar\u0259t üzr\u0259 riskl\u0259rin qiym\u0259tl\u0259ndirilm\u0259si komit\u0259si (PRAC) u\u015faq v\u0259 yetkinl\u0259rd\u0259 a\u011fciy\u0259r x\u0259st\u0259likl\u0259ri il\u0259 \u0259laq\u0259dar yaranan öskür\u0259yin aradan qald\u0131r\u0131lmas\u0131 üçün istifad\u0259 olunan fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259rinin Avropa Birliyind\u0259 qeydiyyat\u0131n\u0131n dayand\u0131r\u0131lmas\u0131 t\u0259klifini ir\u0259li sürüb. Qeydiyyat\u0131n dayand\u0131r\u0131lmas\u0131 pasiyentl\u0259ri qorumaq üçün bir t\u0259dbirdir v\u0259 PRAC QT interval\u0131n\u0131n uzanmas\u0131 v\u0259 “torsades de pointes” (ür\u0259k ritm probleml\u0259rin\u0259 yol aça bil\u0259n ür\u0259yin elektrik f\u0259aliyy\u0259ti anomaliyalar\u0131) riskini n\u0259z\u0259rd\u0259n keçirir. Keçmi\u015fd\u0259 bu d\u0259rmanlar\u0131 q\u0259bul ed\u0259n x\u0259st\u0259l\u0259rd\u0259 ür\u0259k ritminin probleml\u0259ri diqq\u0259t\u0259 çatd\u0131r\u0131l\u0131b. <\/p>\n

Fenspirid v\u0259 ür\u0259k ritm probleml\u0259ri aras\u0131ndak\u0131 potensial \u0259laq\u0259ni ara\u015fd\u0131rmaq üçün fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259rinin insanlarda QT interval\u0131n\u0131n uzatma potensial\u0131na malik oldu\u011funu göst\u0259r\u0259n heyvan t\u0259dqiqatlar\u0131 apar\u0131l\u0131b. PRAC, mövcud olan bütün sübutlar\u0131 ara\u015fd\u0131r\u0131r v\u0259 AB-d\u0259 fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259ri bar\u0259d\u0259 tövsiy\u0259l\u0259r verir. Qiym\u0259tl\u0259ndirm\u0259 ba\u015fa çatd\u0131qdan sonra, EMA m\u0259lumat verm\u0259yi, pasiyent v\u0259 tibb i\u015fçil\u0259rin\u0259 yenil\u0259nmi\u015f r\u0259hb\u0259rlik t\u0259qdim etm\u0259yi planla\u015fd\u0131r\u0131r: "Yuxar\u0131da qeyd edil\u0259nl\u0259ri n\u0259z\u0259r\u0259 alaraq, S\u0259hiyy\u0259 Nazirliyi Farmakoloji v\u0259 Farmakopeya Ekspert \u015euras\u0131 t\u0259r\u0259find\u0259n fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259rinin t\u0259hlük\u0259sizliyi v\u0259 risk-fayda nisb\u0259ti ara\u015fd\u0131r\u0131l\u0131r.<\/p>\n

Ara\u015fd\u0131rmalar\u0131n davam etdiyi müdd\u0259td\u0259 \u0259halinin sa\u011flaml\u0131\u011f\u0131n\u0131n qorunmas\u0131 v\u0259 pasiyentl\u0259rin potensial riskd\u0259n qorunmas\u0131 m\u0259qs\u0259di il\u0259 fenspirid t\u0259rkibli a\u015fa\u011f\u0131dak\u0131 d\u0259rman vasit\u0259l\u0259rinin bütün seriyalar\u0131 geri ça\u011f\u0131r\u0131l\u0131b".<\/p>\n

S\u0259hiyy\u0259 Nazirliyi pasiyentl\u0259rin diqq\u0259tin\u0259 çatd\u0131r\u0131r ki, t\u0259hlük\u0259sizlik m\u0259lumatlar\u0131 göst\u0259rir ki, fenspirid t\u0259rkibli öskür\u0259k \u0259leyhin\u0259 d\u0259rmanlar q\u0259fil ciddi ür\u0259k ritm probleml\u0259rin\u0259 s\u0259b\u0259b ola bil\u0259r: "Pasiyentl\u0259r\u0259 ara\u015fd\u0131rmalar\u0131n davam etdiyi müdd\u0259td\u0259 fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259rinin istifad\u0259sini dayand\u0131rmaq tövsiy\u0259 edilir. Fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259rini istifad\u0259 ed\u0259n pasiyentl\u0259r ür\u0259k ritm probl\u0259rin\u0259 m\u0259ruz qala bil\u0259rl\u0259r. <\/p>\n

\u018fg\u0259r öskür\u0259k \u0259leyhin\u0259 fenspirid t\u0259rkibli d\u0259rman vasit\u0259si q\u0259bul edirsinizs\u0259, alternativ müalic\u0259l\u0259r haqq\u0131nda m\u0259sl\u0259h\u0259t almaq üçün h\u0259kim v\u0259 ya \u0259czaç\u0131ya müraci\u0259t edin. \u018fg\u0259r istifad\u0259 etdiyiniz d\u0259rmanla ba\u011fl\u0131 h\u0259r hans\u0131 narahatl\u0131q varsa, onlar\u0131 h\u0259kim v\u0259 ya \u0259czaç\u0131 il\u0259 müzakir\u0259 edin".<\/p>\n

Tibb i\u015fçil\u0259ri is\u0259 ara\u015fd\u0131rmalar\u0131n davam etdiyi müdd\u0259td\u0259, tibb i\u015fçil\u0259ri pasiyentl\u0259r\u0259 fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259rinin istifad\u0259sinin dayand\u0131r\u0131lmas\u0131n\u0131 m\u0259sl\u0259h\u0259t görm\u0259lidirl\u0259r. Fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259rinin istifad\u0259sinin müv\u0259qq\u0259ti dayand\u0131r\u0131lmas\u0131 son apar\u0131lan klinikaya q\u0259d\u0259r t\u0259dqiqatlara (hERG kanal birl\u0259\u015fm\u0259si v\u0259 in vitro heyvan modell\u0259ri üz\u0259rind\u0259 t\u0259dqiqatlar) \u0259saslan\u0131r v\u0259 fenspiridin insanlarda QT interval\u0131n\u0131n uzanmas\u0131 potensial\u0131na malik oldu\u011funu göst\u0259rir.<\/p>\n

Bu m\u0259lumatlar, fenspirid v\u0259 QT interval\u0131n\u0131n uzanmas\u0131 \/ torsades de pointes aras\u0131ndak\u0131 ehtimal olunan \u015fübh\u0259li \u0259laq\u0259nin olmas\u0131n\u0131 t\u0259sdiql\u0259yir. Fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259rinin simptomatik müalic\u0259 üçün istifad\u0259 olundu\u011funu v\u0259 QT interval\u0131n\u0131n uzamas\u0131n\u0131n ciddiliyi n\u0259z\u0259r\u0259 al\u0131nmaqla, bu t\u0259rkibli d\u0259rmanlar\u0131n t\u0259cili olaraq S\u0259hiyy\u0259 Nazirliyi Farmakoloji v\u0259 Farmakopeya Ekspert \u015euras\u0131n\u0131n yekun q\u0259rar\u0131n\u0131n n\u0259tic\u0259l\u0259rin\u0259 q\u0259d\u0259r t\u0259xir\u0259 sal\u0131n\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"

Az\u0259rbaycanda fenspirid t\u0259rkibli d\u0259rman vasit\u0259l\u0259rinin idxal\u0131, p\u0259rak\u0259nd\u0259 v\u0259 topdan sat\u0131\u015f\u0131 qada\u011fan edilib.  Ucnoqta.az x\u0259b\u0259r verir ki, bu bar\u0259d\u0259 "Report"a S\u0259hiyy\u0259 Nazirliyind\u0259n m\u0259lumat verilib.  Bildirilib ki, Avropa D\u0259rman Agentliyinin 15 fevral tarixli EMA\/114407\/2019 nömr\u0259li “Ür\u0259k…<\/p>\n","protected":false},"author":1,"featured_media":251278,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-77814","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/77814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=77814"}],"version-history":[{"count":0,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/77814\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/media\/251278"}],"wp:attachment":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=77814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=77814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=77814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}