{"id":237439,"date":"2026-01-23T07:05:35","date_gmt":"2026-01-23T03:05:35","guid":{"rendered":""},"modified":"-0001-11-30T00:00:00","modified_gmt":"-0001-11-29T20:00:00","slug":"","status":"publish","type":"post","link":"https:\/\/ucnoqta.az\/?p=237439","title":{"rendered":"Bu bakteriyalar d\u00f6\u015f x\u0259r\u00e7\u0259nginin inki\u015faf\u0131n\u0131 s\u00fcr\u0259tl\u0259ndir\u0259 bil\u0259r"},"content":{"rendered":"

Con Hopkins Kimmel X\u0259rç\u0259ng M\u0259rk\u0259zinin t\u0259dqiqatç\u0131lar\u0131 a\u011f\u0131z bo\u015flu\u011fundak\u0131 bakteriya il\u0259 dö\u015f x\u0259rç\u0259ngi aras\u0131nda \u0259laq\u0259ni a\u015fkar ed\u0259n mühüm bir k\u0259\u015ff etdil\u0259r. <\/strong><\/p>\n

Ucnoqta.az x\u0259b\u0259r verir ki, Periodontitl\u0259 \u0259laq\u0259li oldu\u011fu bilin\u0259n v\u0259 \u0259vv\u0259ll\u0259r kolorektal x\u0259rç\u0259ng üçün risk faktoru kimi mü\u0259yy\u0259n edilmi\u015f bir bakteriya olan Fusobacterium nucleatum-un qan dövran\u0131na daxil olub dö\u015f toxumas\u0131nda yerl\u0259\u015f\u0259 bil\u0259c\u0259yi, iltihaba v\u0259 x\u0259rç\u0259ngönü d\u0259yi\u015fiklikl\u0259r\u0259 s\u0259b\u0259b ola bil\u0259c\u0259yi a\u015fkar edilib.<\/p>\n

Siçanlar v\u0259 insan dö\u015f x\u0259rç\u0259nginin hüceyr\u0259 modell\u0259ri üz\u0259rind\u0259 apar\u0131lan t\u0259crüb\u0259l\u0259rd\u0259 aliml\u0259r bu bakteriyan\u0131n \u015fi\u015f böyüm\u0259sini sür\u0259tl\u0259ndirdiyini v\u0259 a\u011fciy\u0259rl\u0259rd\u0259 x\u0259rç\u0259ng hüceyr\u0259 fraqmentl\u0259rinin istehsal\u0131n\u0131 azaltd\u0131\u011f\u0131n\u0131 a\u015fkar edibl\u0259r. Fusobacterium nucleatum kolonizasiya yerl\u0259rind\u0259 iltihab v\u0259 DNT z\u0259d\u0259l\u0259nm\u0259si il\u0259 mü\u015fayi\u0259t olunan hiperplastik v\u0259 ya metaplastik d\u0259yi\u015fiklikl\u0259r mü\u015fahid\u0259 edilib.<\/p>\n

Bundan \u0259lav\u0259, t\u0259dqiqat bu patologiyadan m\u0259sul olan molekulyar mexanizml\u0259ri a\u015fkar etdi. Bakteriyalar DNT q\u0131r\u0131lmalar\u0131n\u0131n \u0259m\u0259l\u0259 g\u0259lm\u0259sini v\u0259 t\u0259mir mexanizml\u0259rinin aktivl\u0259\u015fm\u0259sini t\u0259\u015fviq edib. Homoloji olmayan birl\u0259\u015fm\u0259 kimi tan\u0131nan DNT uclar\u0131n\u0131n birl\u0259\u015fm\u0259si metodu sür\u0259tli, lakin tez-tez s\u0259hvl\u0259r\u0259 meylli idi v\u0259 mutasiyalar\u0131n ehtimal\u0131n\u0131 art\u0131rd\u0131.<\/p>\n

“Fusobacterium nucleatum”a q\u0131samüdd\u0259tli m\u0259ruz qalma, \u015fi\u015f hüceyr\u0259l\u0259rinin miqrasiyas\u0131 v\u0259 müalic\u0259y\u0259 davaml\u0131l\u0131\u011f\u0131 il\u0259 \u0259laq\u0259li olan DNT-PKcs zülal\u0131n\u0131n istehsal\u0131n\u0131 art\u0131rd\u0131. Bakteriyalar, bakteriyalar\u0131n ba\u011flanmas\u0131n\u0131 asanla\u015fd\u0131ran artan miqdarda spesifik \u015f\u0259k\u0259r\u0259 malik olduqlar\u0131 üçün BRCA1 mutasiyalar\u0131 olan hüceyr\u0259l\u0259r üçün xüsusi t\u0259hlük\u0259 yarad\u0131r. Bu qar\u015f\u0131l\u0131ql\u0131 t\u0259sir daha çox DNT z\u0259d\u0259l\u0259nm\u0259sin\u0259 s\u0259b\u0259b olur v\u0259 \u015fi\u015fin böyüm\u0259sini sür\u0259tl\u0259ndirir.<\/p>\n

T\u0259dqiqat mü\u0259llifl\u0259ri vur\u011fulay\u0131rlar ki, Fusobacterium nucleatum, mövcud mutasiyalar\u0131n t\u0259sirl\u0259rini gücl\u0259ndir\u0259r\u0259k, dö\u015f x\u0259rç\u0259ngin\u0259 genetik meylli \u015f\u0259xsl\u0259r üçün \u0259lav\u0259 risk faktoru ola bil\u0259r.<\/p>\n","protected":false},"excerpt":{"rendered":"

Con Hopkins Kimmel X\u0259rç\u0259ng M\u0259rk\u0259zinin t\u0259dqiqatç\u0131lar\u0131 a\u011f\u0131z bo\u015flu\u011fundak\u0131 bakteriya il\u0259 dö\u015f x\u0259rç\u0259ngi aras\u0131nda \u0259laq\u0259ni a\u015fkar ed\u0259n mühüm bir k\u0259\u015ff etdil\u0259r. Ucnoqta.az x\u0259b\u0259r verir ki, Periodontitl\u0259 \u0259laq\u0259li oldu\u011fu bilin\u0259n v\u0259 \u0259vv\u0259ll\u0259r…<\/p>\n","protected":false},"author":1,"featured_media":251278,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[101],"tags":[],"class_list":["post-237439","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cemiyyet"],"_links":{"self":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/237439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=237439"}],"version-history":[{"count":0,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/237439\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/media\/251278"}],"wp:attachment":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=237439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=237439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=237439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}