{"id":225539,"date":"2025-06-18T08:52:16","date_gmt":"2025-06-18T04:52:16","guid":{"rendered":""},"modified":"-0001-11-30T00:00:00","modified_gmt":"-0001-11-29T20:00:00","slug":"","status":"publish","type":"post","link":"https:\/\/ucnoqta.az\/?p=225539","title":{"rendered":"Viruslar bizi izl\u0259yir:"},"content":{"rendered":"

Yeni bir ara\u015fd\u0131rma göst\u0259rdi ki, viruslar \u0259traf mühitin v\u0259ziyy\u0259ti haqq\u0131nda m\u0259lumatlardan n\u0259 vaxt gözl\u0259m\u0259k v\u0259 n\u0259 vaxt çoxalmaq v\u0259 qopmaq üçün "q\u0259rar verm\u0259k" üçün istifad\u0259 edir v\u0259 ana hüceyr\u0259ni öldürür.<\/strong><\/p>\n

Ucnoqta.az x\u0259b\u0259r verir ki, Merilend Universitetinin (Baltimore County) (AB\u015e) aliml\u0259ri t\u0259r\u0259find\u0259n apar\u0131lan yeni bir ara\u015fd\u0131rma sübut edib ki, viruslar \u0259traf mühitd\u0259n g\u0259l\u0259n m\u0259lumatlardan istifad\u0259 ed\u0259r\u0259k, ev sahibinin içind\u0259 n\u0259 vaxt qalaca\u011f\u0131na v\u0259 n\u0259 vaxt çoxal\u0131b ç\u0131xaca\u011f\u0131na “q\u0259rar verm\u0259k” üçün ana hüceyr\u0259ni öldürürl\u0259r. \u0130\u015fin antiviral d\u0259rmanlar\u0131n inki\u015faf\u0131 üçün t\u0259siri var. Elmi m\u0259qal\u0259 “Frontiers in Microbiolog” jurnal\u0131nda d\u0259rc olunub v\u0259 universitetd\u0259n m\u0259lumat verilib.<\/p>\n

Biologiya professoru v\u0259 yeni m\u0259qal\u0259nin ba\u015f mü\u0259llifi \u0130van Erill deyir: "Virusun öz mühitini hiss etm\u0259k qabiliyy\u0259ti virusla ev sahibi aras\u0131nda qar\u015f\u0131l\u0131ql\u0131 \u0259laq\u0259y\u0259 daha bir mür\u0259kk\u0259blik qat\u0131 \u0259lav\u0259 edir. Haz\u0131rda viruslar bu qabiliyy\u0259td\u0259n öz xeyirl\u0259rin\u0259 istifad\u0259 edirl\u0259r. Lakin g\u0259l\u0259c\u0259kd\u0259 biz bundan onlar\u0131n z\u0259r\u0259rin\u0259 istifad\u0259 ed\u0259 bil\u0259rik".
\nYeni t\u0259dqiqat bakteriofaqlara, bakteriyalar\u0131 yoluxduran viruslara, tez-tez sad\u0259c\u0259 "faglar" adland\u0131r\u0131lan viruslara diqq\u0259t yetirdi. Bu t\u0259dqiqatda t\u0259dqiq edil\u0259n faqlar yaln\u0131z bakteriya hüceyr\u0259l\u0259rind\u0259 bakteriyalar\u0131n h\u0259r\u0259k\u0259t etm\u0259sin\u0259 v\u0259 cütl\u0259\u015fm\u0259sin\u0259 köm\u0259k ed\u0259n xüsusi \u0259lav\u0259l\u0259r, pili v\u0259 flagella olduqda ev sahibl\u0259rin\u0259 yoluxa bil\u0259r. Bakteriyalar pilil\u0259rin böyüm\u0259sini idar\u0259 ed\u0259n CtrA adl\u0131 bir protein istehsal edir.<\/p>\n

Yeni m\u0259qal\u0259 göst\u0259rir ki, bir çox \u0259lav\u0259d\u0259n as\u0131l\u0131 faqlar\u0131n DNT-l\u0259rind\u0259 CtrA zülal\u0131n\u0131n varl\u0131\u011f\u0131n\u0131 hiss ed\u0259 v\u0259 ona yap\u0131\u015fa bil\u0259n bölg\u0259l\u0259r var. Bu bölg\u0259l\u0259r\u0259 ba\u011flay\u0131c\u0131 yerl\u0259r deyilir. Daha da t\u0259\u0259ccüblü odur ki, \u0259trafl\u0131 genomik analiz bu ba\u011flanma yerl\u0259rinin h\u0259r hans\u0131 bir faja, h\u0259tta h\u0259r hans\u0131 bir qrupa xas olmad\u0131\u011f\u0131n\u0131 ortaya qoydu. Bir çox müxt\u0259lif növ viruslar CtrA üçün ba\u011flay\u0131c\u0131 saytlara malikdir. Onlar\u0131n ham\u0131s\u0131 ev sahibl\u0259rind\u0259n yoluxmaq üçün pili v\u0259\/v\u0259 ya flagella olmas\u0131n\u0131 t\u0259l\u0259b edirdi. Bu t\u0259sadüf ola bilm\u0259zdi. Y\u0259ni, CtrA s\u0259viyy\u0259l\u0259rin\u0259 n\u0259zar\u0259t etm\u0259k qabiliyy\u0259ti t\u0259kamül zaman\u0131 müxt\u0259lif bakteriyalar\u0131 yoluxduran müxt\u0259lif faqlar t\u0259r\u0259find\u0259n bir neç\u0259 d\u0259f\u0259 icad edilmi\u015fdir.<\/p>\n

Yeni ara\u015fd\u0131rmada ilk d\u0259f\u0259 mü\u0259yy\u0259n edil\u0259n delta faqda CtrA ba\u011flama yerl\u0259ri var
\nBu hekay\u0259nin ba\u015fqa bir dönü\u015fü: T\u0259dqiqat qrupunun CtrA ba\u011flama yerl\u0259ri il\u0259 mü\u0259yy\u0259n etdiyi ilk faq, Caulobacterales adl\u0131 xüsusi bir bakteriya qrupunu yoluxdurur. Caulobacterales iki formada olur: s\u0259rb\u0259st üz\u0259n "sürücü" forma v\u0259 s\u0259thl\u0259r\u0259 yap\u0131\u015fan "sap" formas\u0131. Swarmers pili \/ flagella var, budaqlar\u0131 is\u0259 yoxdur.<\/p>\n

Faglar yaln\u0131z sürücü hüceyr\u0259l\u0259r\u0259 yoluxa bildiyin\u0259 gör\u0259, onlar\u0131n maraq dair\u0259sind\u0259 çoxlu sürü hüceyr\u0259l\u0259r olduqda ev sahibini t\u0259rk etm\u0259k daha yax\u015f\u0131d\u0131r. Caulobacterales ad\u0259t\u0259n qida çat\u0131\u015fmazl\u0131\u011f\u0131 olan mühitl\u0259rd\u0259 ya\u015fay\u0131r v\u0259 çox s\u0259p\u0259l\u0259nmi\u015fdir.<\/p>\n

"Ancaq onlar yax\u015f\u0131 mikromühit cibini tapd\u0131qda, sapl\u0131 hüceyr\u0259l\u0259r\u0259 çevrilirl\u0259r v\u0259 çoxal\u0131rlar v\u0259 n\u0259tic\u0259d\u0259 çoxlu sayda sürü hüceyr\u0259l\u0259r \u0259m\u0259l\u0259 g\u0259tirirl\u0259r. Biz f\u0259rz edirik ki, faqlar hüceyr\u0259nin h\u0259yat dövrü \u0259rzind\u0259 yüks\u0259l\u0259n v\u0259 azalan CtrA s\u0259viyy\u0259l\u0259rini izl\u0259yirl\u0259r ki, bir sürü hüceyr\u0259nin n\u0259 vaxt t\u0259qib edildiyini v\u0259 çoxlu hüceyr\u0259y\u0259 çevrildiyini anlamaq üçün onlar çoxlu hüceyr\u0259y\u0259 çevril\u0259c\u0259kl\u0259r. yoluxdurmaq üçün yax\u0131nl\u0131qdak\u0131 ovçular”.<\/p>\n

N\u0259tic\u0259l\u0259r daha maraql\u0131d\u0131r.
\n"Göst\u0259rildi ki, faglar haqq\u0131nda bildiyimiz h\u0259r \u015fey, onlar\u0131n inki\u015faf etdirdiyi h\u0259r bir t\u0259kamül strategiyas\u0131 bitki v\u0259 heyvanlar\u0131 yoluxduran viruslara ötürül\u0259 bil\u0259r. Bu, dem\u0259k olar ki, verilmi\u015fdir. Dem\u0259li, faglar öz ev sahibl\u0259rini t\u0259hlil ets\u0259l\u0259r, insanlar\u0131 yoluxduran viruslar da mütl\u0259q eyni \u015feyi ed\u0259c\u0259kl\u0259r", – alim izah edir.
\nM\u0259s\u0259l\u0259n, bir heyvan virusu onun hans\u0131 toxumada oldu\u011funu v\u0259 ya ev sahibinin immun reaksiyas\u0131n\u0131n n\u0259 q\u0259d\u0259r güclü oldu\u011funu "bilm\u0259k ist\u0259y\u0259 bil\u0259r". Bu, yeni müalic\u0259l\u0259r üçün imkanlar aç\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"

Yeni bir ara\u015fd\u0131rma göst\u0259rdi ki, viruslar \u0259traf mühitin v\u0259ziyy\u0259ti haqq\u0131nda m\u0259lumatlardan n\u0259 vaxt gözl\u0259m\u0259k v\u0259 n\u0259 vaxt çoxalmaq v\u0259 qopmaq üçün "q\u0259rar verm\u0259k" üçün istifad\u0259 edir v\u0259 ana hüceyr\u0259ni öldürür.…<\/p>\n","protected":false},"author":1,"featured_media":251278,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[100],"tags":[],"class_list":["post-225539","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diger"],"_links":{"self":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/225539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=225539"}],"version-history":[{"count":0,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/225539\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/media\/251278"}],"wp:attachment":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=225539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=225539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=225539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}