{"id":204229,"date":"2024-06-20T16:04:40","date_gmt":"2024-06-20T12:04:40","guid":{"rendered":""},"modified":"-0001-11-30T00:00:00","modified_gmt":"-0001-11-29T20:00:00","slug":"","status":"publish","type":"post","link":"https:\/\/ucnoqta.az\/?p=204229","title":{"rendered":"Az\u0259rbaycan, T\u00fcrkiy\u0259 v\u0259 Rusiyan\u0131n kimya\u00e7\u0131 aliml\u0259ri m\u00fch\u00fcm elmi n\u0259tic\u0259 \u0259ld\u0259 edibl\u0259r"},"content":{"rendered":"

Az\u0259rbaycan Respublikas\u0131 Elm v\u0259 T\u0259hsil Nazirliyi akademik \u018fli Quliyev ad\u0131na A\u015fqarlar Kimyas\u0131 \u0130nstitutunun apar\u0131c\u0131 aliml\u0259rinin Rusiyan\u0131n \u0130rkutsk Kimya \u0130nstitutu v\u0259 Türkiy\u0259nin Atatürk v\u0259 Bartin universitetl\u0259rind\u0259n olan h\u0259mkarlar\u0131 il\u0259 “Asetilxolinesteraza (AChE) v\u0259 α-qlikozidazan\u0131n (α-Gly) ikili inhibitorlar\u0131 kimi yeni v\u0259 yüks\u0259k aktivlikd\u0259 olan pirrol-heterosikl tör\u0259m\u0259l\u0259rinin sintezi, “in vitro” v\u0259 “in vivo” bioloji f\u0259all\u0131\u011f\u0131n\u0131n t\u0259dqiqi” mövzusunda apard\u0131qlar\u0131 beyn\u0259lxalq s\u0259viyy\u0259li mü\u015ft\u0259r\u0259k t\u0259dqiqatlar zaman\u0131 növb\u0259ti mühüm n\u0259tic\u0259l\u0259r \u0259ld\u0259 olunmu\u015fdur.<\/strong><\/p>\n

\u0130nstitutun \u0130ctimaiyy\u0259tl\u0259 \u0259laq\u0259l\u0259r \u015föb\u0259sind\u0259n Ucnoqta.az-a veril\u0259n m\u0259lumata gör\u0259, h\u0259min mühüm n\u0259tic\u0259l\u0259r “Web of Science” bazas\u0131nda arxivl\u0259\u015fdiril\u0259n Q2 kateqoriyal\u0131 impakt faktoru 4.06 olan dünyaca m\u0259\u015fhur “Elsevier” n\u0259\u015friyyat\u0131n\u0131n  “Journal Molecular Structure” jurnal\u0131nda müf\u0259ss\u0259l ara\u015fd\u0131rma m\u0259qal\u0259si kimi (Ol'ga V. Petrova, Denis N. Tomilin, Halil \u015eenol, Kseniya V. Belyaeva, Lina P. Nikitina, Ludmila A. Oparina, Lyubov N. Sobenina, Boris A. Trofimov, Nastaran Sadeghian, Parham Taslimi, Vagif Farzaliyev, Afsun Sujayev, \u0130lhami Gulçin, Synthesis of pyrrole-heterocyclic derivatives as anti-Alzheimer and antidiabetic candidates: An in vitro-in silico study, Journal of Molecular Structure, 2024, 1315, 138998, https:\/\/doi.org\/10.1016\/j.molstruc.2024.138998) d\u0259rc olunub.<\/p>\n

M\u0259lumatda qeyd edilir ki, \u0259lveri\u015fli farmakokinetik profill\u0259r\u0259 malik AChE v\u0259 α-Gly fermentl\u0259ri güclü inhib\u0259 nümayi\u015f etdir\u0259n yeni n\u0259sil inhibitorlar\u0131n analoqlar\u0131 il\u0259 müqayis\u0259d\u0259 daha t\u0259sirli oldu\u011fu m\u0259lum olmu\u015fdur. Bioloji f\u0259all\u0131qlar\u0131n molekulyar dokinq, dinamika simulyasiya v\u0259 ADME proqnozla\u015fma çal\u0131\u015fmalar\u0131 bel\u0259 bir n\u0259tic\u0259y\u0259 g\u0259lm\u0259y\u0259 imkan vermi\u015fdir ki, bu birl\u0259\u015fm\u0259l\u0259r AChE v\u0259 α-Gly üçün seçici inhibitor olmaq potensial\u0131na sahibdirl\u0259r. Xüsus\u0259n, yeni yarad\u0131lan inhibitorlar yax\u0131n g\u0259l\u0259c\u0259kd\u0259 Alzeymer x\u0259st\u0259liyi v\u0259 \u015f\u0259k\u0259rli diabet d\u0259 daxil olmaqla, dünyada geni\u015f yay\u0131lan b\u0259zi qlobal x\u0259st\u0259likl\u0259rin müalic\u0259si üçün yeni bioloji \u0259lav\u0259l\u0259rin inki\u015faf\u0131na köm\u0259k ed\u0259 bil\u0259r. 
\n <\/p>\n","protected":false},"excerpt":{"rendered":"

Az\u0259rbaycan Respublikas\u0131 Elm v\u0259 T\u0259hsil Nazirliyi akademik \u018fli Quliyev ad\u0131na A\u015fqarlar Kimyas\u0131 \u0130nstitutunun apar\u0131c\u0131 aliml\u0259rinin Rusiyan\u0131n \u0130rkutsk Kimya \u0130nstitutu v\u0259 Türkiy\u0259nin Atatürk v\u0259 Bartin universitetl\u0259rind\u0259n olan h\u0259mkarlar\u0131 il\u0259 “Asetilxolinesteraza (AChE)…<\/p>\n","protected":false},"author":1,"featured_media":251278,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[101],"tags":[],"class_list":["post-204229","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cemiyyet"],"_links":{"self":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/204229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=204229"}],"version-history":[{"count":0,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/204229\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/media\/251278"}],"wp:attachment":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=204229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=204229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=204229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}