{"id":202779,"date":"2024-05-24T00:27:55","date_gmt":"2024-05-23T20:27:55","guid":{"rendered":""},"modified":"-0001-11-30T00:00:00","modified_gmt":"-0001-11-29T20:00:00","slug":"","status":"publish","type":"post","link":"https:\/\/ucnoqta.az\/?p=202779","title":{"rendered":"Prostat v\u0259zi x\u0259r\u00e7\u0259nginin m\u00fcalic\u0259sind\u0259"},"content":{"rendered":"

Viskonsin Tibb Kollecinin aliml\u0259ri Stat5 adl\u0131 spesifik zülal\u0131n aktivliyini azaltma\u011fa \u0259saslanan prostat x\u0259rç\u0259ngi üçün yeni müalic\u0259 üsulu haz\u0131rlay\u0131blar. Bu zülal\u0131n qar\u015f\u0131s\u0131n\u0131 almaq daha t\u0259hlük\u0259li, kastrata davaml\u0131 prostat x\u0259rç\u0259nginin inki\u015faf\u0131n\u0131n qar\u015f\u0131s\u0131n\u0131 al\u0131r. <\/strong><\/p>\n

Ucnoqta.az x\u0259b\u0259r verir ki, t\u0259dqiqat\u0131n n\u0259tic\u0259l\u0259ri Science Advances (SciAdv) jurnal\u0131nda d\u0259rc olunub.
\nAliml\u0259r izah edibl\u0259r ki, prostat x\u0259rç\u0259ngi çox vaxt androgen deprivasiya terapiyas\u0131 il\u0259 müalic\u0259 olunur. Bu prosedur zaman\u0131 \u015fi\u015f hüceyr\u0259l\u0259rinin m\u0259hvini stimulla\u015fd\u0131rmaq üçün testosteronun (ki\u015fi cinsi hormonu) s\u0259viyy\u0259si süni \u015f\u0259kild\u0259 azald\u0131l\u0131r. Bununla bel\u0259, bu terapiya cinsi disfunksiya v\u0259 ç\u0259ki art\u0131m\u0131 da daxil olmaqla yan t\u0259sirl\u0259r\u0259 malikdir.
\nBundan \u0259lav\u0259, androgen m\u0259hrumiyy\u0259ti terapiyas\u0131 il\u0259, h\u0259tta a\u015fa\u011f\u0131 testosteron s\u0259viyy\u0259l\u0259rind\u0259 d\u0259 t\u0259hlük\u0259li kastrata davaml\u0131 prostat x\u0259rç\u0259ngi inki\u015faf riski var. Bu, androgen reseptoru adlanan zülaldak\u0131 müxt\u0259lif mutasiyalar n\u0259tic\u0259sind\u0259 ba\u015f ver\u0259 bil\u0259r.<\/p>\n

Proteini daha t\u0259hlük\u0259siz \u015f\u0259kild\u0259 h\u0259d\u0259fl\u0259m\u0259k üçün elm adamlar\u0131 Stat5-i mane\u0259 tör\u0259d\u0259n bir d\u0259rman haz\u0131rlad\u0131lar. Bu, androgen reseptorlar\u0131n\u0131n f\u0259aliyy\u0259tini stimulla\u015fd\u0131ran v\u0259 bununla da prostat x\u0259rç\u0259nginin böyüm\u0259sini t\u0259\u015fviq ed\u0259n ba\u015fqa bir \u0259lav\u0259 proteindir.<\/p>\n

D\u0259rman\u0131n effektivliyi art\u0131q laboratoriya siçanlar\u0131 üz\u0259rind\u0259 s\u0131naqdan keçirilib. N\u0259tic\u0259l\u0259r göst\u0259rdi ki, Stat5 f\u0259aliyy\u0259tinin qar\u015f\u0131s\u0131n\u0131n al\u0131nmas\u0131 mövcud x\u0259rç\u0259ngl\u0259rin böyüm\u0259sini l\u0259ngidir v\u0259 androgen reseptorlar\u0131n\u0131 bloklay\u0131r v\u0259 bununla da kastrata davaml\u0131 x\u0259rç\u0259ngl\u0259rin inki\u015faf riskini azald\u0131r.<\/p>\n

\u0130ndi aliml\u0259r yeni inki\u015faf\u0131 t\u0259kmill\u0259\u015fdirm\u0259y\u0259 davam etm\u0259yi planla\u015fd\u0131r\u0131rlar. G\u0259l\u0259c\u0259k t\u0259dqiqatlar Stat5 inhibitor d\u0259rman\u0131n\u0131 könüllül\u0259r üz\u0259rind\u0259 s\u0131naqdan keçir\u0259c\u0259k.<\/p>\n","protected":false},"excerpt":{"rendered":"

Viskonsin Tibb Kollecinin aliml\u0259ri Stat5 adl\u0131 spesifik zülal\u0131n aktivliyini azaltma\u011fa \u0259saslanan prostat x\u0259rç\u0259ngi üçün yeni müalic\u0259 üsulu haz\u0131rlay\u0131blar. Bu zülal\u0131n qar\u015f\u0131s\u0131n\u0131 almaq daha t\u0259hlük\u0259li, kastrata davaml\u0131 prostat x\u0259rç\u0259nginin inki\u015faf\u0131n\u0131n qar\u015f\u0131s\u0131n\u0131…<\/p>\n","protected":false},"author":1,"featured_media":251278,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-202779","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/202779","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=202779"}],"version-history":[{"count":0,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/202779\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/media\/251278"}],"wp:attachment":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=202779"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=202779"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=202779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}