{"id":186983,"date":"2023-09-29T17:06:34","date_gmt":"2023-09-29T13:06:34","guid":{"rendered":""},"modified":"-0001-11-30T00:00:00","modified_gmt":"-0001-11-29T20:00:00","slug":"","status":"publish","type":"post","link":"https:\/\/ucnoqta.az\/?p=186983","title":{"rendered":"M\u00fc\u0259yy\u0259n genin nasazl\u0131\u011f\u0131 x\u0259r\u00e7\u0259ng h\u00fcceyr\u0259l\u0259rinin \u00e7oxalmas\u0131n\u0131 s\u00fcr\u0259tl\u0259ndirir"},"content":{"rendered":"

Kanadan\u0131n Toronto Universitetinin t\u0259dqiqatç\u0131lar\u0131 b\u0259dxass\u0259li \u015fi\u015fl\u0259rin sür\u0259tl\u0259 böyüm\u0259sin\u0259 s\u0259b\u0259b olan gen a\u015fkar edibl\u0259r. M\u0259lum olub ki, SOX2-nin düzgün i\u015fl\u0259m\u0259m\u0259si sidik kis\u0259si, u\u015faql\u0131q yolu, dö\u015f v\u0259 a\u011fciy\u0259r x\u0259rç\u0259ngin\u0259 s\u0259b\u0259b ola bil\u0259r. Aliml\u0259r t\u0259dqiqat\u0131n n\u0259tic\u0259l\u0259rini Nucleic Acids Research (NAR) jurnal\u0131nda payla\u015f\u0131blar.<\/strong><\/p>\n

T\u0259dqiqatç\u0131lar x\u0259rç\u0259ng hüceyr\u0259l\u0259rind\u0259 SOX2 genini n\u0259yin aktivl\u0259\u015fdirdiyini v\u0259 onlar\u0131n n\u0259zar\u0259tsiz \u015f\u0259kild\u0259 çoxalmas\u0131na s\u0259b\u0259b oldu\u011funu anlamaq ist\u0259yibl\u0259r. M\u0259lum olub ki, SOX2 DNT-d\u0259ki mutasiyalar v\u0259 ya z\u0259d\u0259l\u0259nm\u0259l\u0259r s\u0259b\u0259bind\u0259n \u015fi\u015f böyüm\u0259sini stimulla\u015fd\u0131rm\u0131r. \u0130nsan\u0131n h\u0259yat\u0131 boyu onun genomunu t\u0259\u015fkil ed\u0259n 30 min genin çoxu h\u0259r\u0259k\u0259tsizdir. Bu o dem\u0259kdir ki, genl\u0259r hüceyr\u0259 zülal kodla\u015fd\u0131rma mexanizml\u0259rini i\u015f\u0259 salm\u0131r.<\/p>\n

Aliml\u0259r a\u015fkar edibl\u0259r ki, genomun SOX2-ni ehtiva ed\u0259n hiss\u0259si aç\u0131q qala bil\u0259r ki, bu da genin hüceyr\u0259l\u0259rin x\u0259rç\u0259ng\u0259 çevrilm\u0259sini stimulla\u015fd\u0131rmas\u0131na s\u0259b\u0259b olur. Bu gen h\u0259mçinin iki zülal kodlay\u0131r – FOXA1 v\u0259 NFIB. NFIB x\u0259rç\u0259ng hüceyr\u0259l\u0259rinin çoxalma mexanizmini bo\u011fur, FOXA1 is\u0259 \u0259ksin\u0259 onu aktivl\u0259\u015fdirir.<\/p>\n

T\u0259dqiqat mü\u0259llifl\u0259ri qeyd edibl\u0259r ki, NFIB zülal\u0131n\u0131n f\u0259aliyy\u0259tini gücl\u0259ndir\u0259c\u0259k d\u0259rmanlar\u0131n haz\u0131rlanmas\u0131 dö\u015f, u\u015faql\u0131q yolu, sidik kis\u0259si v\u0259 a\u011fciy\u0259r x\u0259rç\u0259nginin müalic\u0259sind\u0259 ir\u0259lil\u0259yi\u015f \u0259ld\u0259 etm\u0259y\u0259 köm\u0259k ed\u0259c\u0259k.<\/p>\n

\u018fvv\u0259ll\u0259r b\u0259dxass\u0259li hüceyr\u0259l\u0259ri normal v\u0259ziyy\u0259t\u0259 qaytarma\u011f\u0131n bir yolu tap\u0131ld\u0131.<\/p>\n","protected":false},"excerpt":{"rendered":"

Kanadan\u0131n Toronto Universitetinin t\u0259dqiqatç\u0131lar\u0131 b\u0259dxass\u0259li \u015fi\u015fl\u0259rin sür\u0259tl\u0259 böyüm\u0259sin\u0259 s\u0259b\u0259b olan gen a\u015fkar edibl\u0259r. M\u0259lum olub ki, SOX2-nin düzgün i\u015fl\u0259m\u0259m\u0259si sidik kis\u0259si, u\u015faql\u0131q yolu, dö\u015f v\u0259 a\u011fciy\u0259r x\u0259rç\u0259ngin\u0259 s\u0259b\u0259b ola bil\u0259r. Aliml\u0259r…<\/p>\n","protected":false},"author":1,"featured_media":251278,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[89],"tags":[],"class_list":["post-186983","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya-butun-xeberler"],"_links":{"self":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/186983","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=186983"}],"version-history":[{"count":0,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/posts\/186983\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=\/wp\/v2\/media\/251278"}],"wp:attachment":[{"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=186983"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=186983"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ucnoqta.az\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=186983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}